In vitro adsorption of gentamicin and netilmicin by polyacrylonitrile and polyamide hemofiltration filters.
نویسندگان
چکیده
Adsorption of gentamicin and netilmicin by new polyacrylonitrile and polyamide hemofiltration filters was studied over 4 h, using a single-compartment in vitro continuous venovenous hemofiltration model. After the first dose (16.6 mg of gentamicin, 19.3 mg of netilmicin), 14.9 mg of gentamicin and 19.2 mg of netilmicin were adsorbed to polyacrylonitrile filters in vitro. Adsorption by polyacrylonitrile filters was rapid and irreversible and could be increased by repeated dosing. Adsorption by polyamide filters was substantially less.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 54 2 شماره
صفحات -
تاریخ انتشار 2010